Marfan syndrome and mitral valve prolapse.
نویسندگان
چکیده
Mitral valve prolapse (MVP), an abnormal displacement into the left atrium of a thickened and redundant mitral valve during systole, is a relatively frequent abnormality in humans and may be associated with serious complications. A recent study implicates fibrillin-1, a component of extracellular matrix microfibrils, in the pathogenesis of a murine model of MVP. This investigation represents an initial step toward understanding the mechanisms involved in human MVP disease and the development of potential treatments.
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 114 11 شماره
صفحات -
تاریخ انتشار 2004